Per vaccine models can be designed to test the safety. For example, for pertussis toxin vaccine.
Publications
- Vaessen SF, Bruysters MW, Vandebriel RJ, Verkoeijen S, Bos R, Krul CA, Akkermans AM.
Toward a mechanism-based in vitro safety test for pertussis toxin.
Hum Vaccin Immunother. 2014;10(5):1391-5. - Vaessen SF, Verkoeijen S, Vandebriel RJ, Bruysters MW, Pennings JL, Bos R, Krul CA, Akkermans AM.
Identification of biomarkers to detect residual pertussis toxin using microarray analysis of dendritic cells.
Vaccine. 2013 Oct 25;31(45):5223-31.