Keratinocytes and skin models are used to determine whether chemicals in cosmetics, for example, may have a contact-allergenic effect. At iLab, the methods are standardized.
Publications
- Teunis MA, Spiekstra SW, Smits M, Adriaens E, Eltze T, Galbiati V, Krul C, Landsiedel R, Pieters R, Reinders J, Roggen E, Corsini E, Gibbs S.
International ring trial of the epidermal equivalent sensitizer potency assay: reproducibility and predictive-capacity.
ALTEX. 2014;31(3):251-68 -
Teunis M, Corsini E, Smits M, Madsen CB, Eltze T, Ezendam J, Galbiati V, Gremmer E, Krul C, Landin A, Landsiedel R, Pieters R, Rasmussen TF, Reinders J, Roggen E, Spiekstra S, Gibbs S.
Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency.
Toxicol In Vitro. 2013 Apr;27(3):1135-50.
