Gut models (cell lines, organoids) are used for the measurement of induction and inhibition of intestinal injury, and the inclusion and degradation of substances (for example drugs or proteins). In organoids also specific effects of substances (foods, medicines and other chemicals) can be determined. The bowel models are also used to test antibacterial activity of natural substances.
Publications
Cell lines
- Allijn IE, Vaessen SF, Quarles van Ufford LC, Beukelman KJ, de Winther MP, Storm G, Schiffelers RM.
Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro.
PLoS One. 2016 May 10;11(5)
Stem cell organoids
- van der Wielen N, Ten Klooster JP, Muckenschnabl S, Pieters R, Hendriks HF, Witkamp RF, Meijerink J.
The Noncaloric Sweetener Rebaudioside A Stimulates Glucagon-Like Peptide 1 Release and Increases Enteroendocrine Cell Numbers in 2-Dimensional Mouse Organoids Derived from Different Locations of the Intestine.
J Nutr. 2016 Oct 26. pii: jn232678. [Epub ahead of print]
- CarinBiel, EmiliaBigaeva,MelanieHesse, Jordy J.M.Bomers,Kittyvan Summeren, Marc A.T.Teunis, StefanVaessen, .PeterOlinga.
Survival and cellular heterogeneity of epithelium in cultured mouse and rat precision-cut intestinal slices
Toxicology in Vitro, Volume 69, Dec 2020, https://doi.org/10.1016/j.tiv.2020.104974
